Effect of Magnetic Fluid Hyperthermia on Implanted Melanoma in Mouse Models

نویسندگان

  • Alireza Mehdizadeh Department of Medical Physics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran; and Nanomedicine and Nanobiology Research Center, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
  • Amirhossein Rajaei Department of Electrical and Electronic, School of Electrical and Electronic Engineering, Shiraz University of Technology, Shiraz, Iran
  • Hossein Heli Department of Nanomedicine, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran
  • Maryam Heidari Department of Medical Physics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran; and Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran
  • Naghmeh Sattarahmady Department of Medical Physics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran; and Nanomedicine and Nanobiology Research Center, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
  • Negar Azarpira Transplant Research Center, Department of Pathology, Namazee Teaching Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
  • Sirus Javadpour Department of Materials Science and Engineering, School of Electrical and Computer Engineering, Shiraz University, Shiraz, Iran
  • Tahereh Zare Department of Medical Physics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran; and Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده مقاله:

Background: Nowadays, magnetic nanoparticles (MNPs) have received much attention because of their enormous potentials in many fields such as magnetic fluid hyperthermia (MFH). The goal of hyperthermia is to increase the temperature of malignant cells to destroy them without any lethal effect on normal tissues. To investigate the effectiveness of cancer therapy by magnetic fluid hyperthermia, Fe0.5Zn0.5Fe2O4 nanoparticles (FNPs) were used to undergo external magnetic field (f=515 kHz, H=100 G) in mice bearing implanted tumor.Methods: FNPs were synthesized via precipitation and characterized using transmission electron microscopy (TEM), vibrating sample magnetometer, and Fourier transform infrared. For in vivo study, the mice bearing implanted tumor were divided into four groups (two mice per group), namely, control group, AMF group, MNPs group, and MNPs&AMF group. After 24 hours, the mice were sacrificed and each tumor specimen was prepared for histological analyses. The necrotic surface area was estimated by using graticule (Olympus, Japan) on tumor slides.Results: The mean diameter of FNPs was estimated around 9 nm by TEM image and M versus H curve indicates that this particle is among superparamagnetic materials. According to histological analyses, no significant difference in necrosis extent was observed among the four groups.Conclusion: FNPs are biocompatible and have a good size for biomedical applications. However, for MFH approach, larger diameters especially in the range of ferromagnetic particles due to hysteresis loss can induce efficient heat in the target region.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

effect of magnetic fluid hyperthermia on implanted melanoma in mouse models

background: nowadays, magnetic nanoparticles (mnps) have received much attention because of their enormous potentials in many fields such as magnetic fluid hyperthermia (mfh). the goal of hyperthermia is to increase the temperature of malignant cells to destroy them without any lethal effect on normal tissues. to investigate the effectiveness of cancer therapy by magnetic fluid hyperthermia, fe...

متن کامل

Simulation of tissue heating by magnetic fluid hyperthermia

Objective: Magnetic fluid hyperthermia is a technique in which thermal energy is generated by magnetic nanoparticles (MNPs) that are excited by an alternating magnetic field (AC field). During hyperthermia, in-vivo monitoring of elevation of temperature relies on invasive insertion of conventional thermometers, or employment of thermo-sensitive cameras that lack high precision....

متن کامل

Effect of magnetic fluid hyperthermia with dendrimer coated iron oxide nanoparticles on breast cancer in BALB/c mice

Introduction: Magnetic fluid hyperthermia (MFH) is a promising therapeutic method in cancer therapy with using magnetic nanoparticles (NPs). In this study, we assessed the effect of MFH on mechanisms of cell death in murine breast cancer cell line (MC4-L2) and also the treatment of breast tumor in BALB/C mice using four generation dendrimer coated iron oxide nanoparticles (G4@I...

متن کامل

Effect of hyperthermia on experimental choroidal melanoma.

Thirty-five rabbit eyes were implanted subchoroidally with Greene's hamster melanoma. When the tumours reached a base diameter of 5 mm, they were treated with ultrasonically induced hyperthermia with a range of temperatures and exposure durations (43-67 degrees C and 75 s to 60 min). Of the 23 treated eyes examined two months after treatment eight showed complete regression of the tumour. Seven...

متن کامل

the washback effect of discretepoint vs. integrative tests on the retention of content in knowledge tests

در این پایان نامه تاثیر دو نوع تست جزیی نگر و کلی نگر بر به یادسپاری محتوا ارزیابی شده که نتایج نشان دهندهکارایی تستهای کلی نگر بیشتر از سایر آزمونها است

15 صفحه اول

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ذخیره در منابع من قبلا به منابع من ذحیره شده

{@ msg_add @}


عنوان ژورنال

دوره 41  شماره 4

صفحات  314- 321

تاریخ انتشار 2016-07-01

با دنبال کردن یک ژورنال هنگامی که شماره جدید این ژورنال منتشر می شود به شما از طریق ایمیل اطلاع داده می شود.

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023